![]() ![]() Second, we review the data for the Tlc of mice. First, we show that humans routinely occupy environments about 3 ☌ below their lower critical temperature (Tlc), which when lightly clothed is about 23 ☌. In the current paper we challenge this notion. Group housing or providing the mice with bedding and nesting material might lower this to about 20–22 ☌, close to current standard practice.ĪB - It has been argued that mice should be housed at 30 ☌ to best mimic the thermal conditions experienced by humans, and that the current practice of housing mice at 20–22 ☌ impairs the suitability of mice as a model for human physiology and disease. ![]() The equivalent temperature to that normally experienced by humans for most single housed adult mice is therefore 23–25 ☌. Mouse Tlc is dependent on body weight and about 26–28 ☌ for adult mice weighing >25 g. N2 - It has been argued that mice should be housed at 30 ☌ to best mimic the thermal conditions experienced by humans, and that the current practice of housing mice at 20–22 ☌ impairs the suitability of mice as a model for human physiology and disease. T1 - Not so hot: Optimal housing temperatures for mice to mimic the thermal environment of human
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